Avodah Zarah4: 5
כֵּיצַד מְבַטְּלָהּ? קָטַע רֹאשׁ אָזְנָהּ, רֹאשׁ חָטְמָהּ, רֹאשׁ אֶצְבָּעָהּ, פְּחָסָהּ אַף עַל פִּי שֶׁלֹּא חִסְּרָהּ — בִּטְּלָהּ. רָקַק בְּפָנֶיהָ, הִשְׁתִּין בְּפָנֶיהָ, גֵּרְרָהּ, וְזָרַק בָּהּ אֶת הַצּוֹאָה — הֲרֵי זוֹ אֵינָהּ בְּטֵלָה. מְכָרָהּ אוֹ מִשְׁכְּנָהּ — רַבִּי אוֹמֵר: בִּטֵּל, וַחֲכָמִים אוֹמְרִים: לֹא בִטֵּל.
How does he nullify it? [If] he cut off the tip of its ear, the tip of its nose, the tip of its finger, [or] he dented it even though he did not diminish it —- he has nullified it. [If] he spit in front of it, urinated in front of it, dragged it [through mud], or threw excrement at it —- it is not nullified. [If] he sold it or gave it as a pledge, Rabbi says: He has nullified [it]. But the Sages say: He has not nullified [it].